Premium
Primary leiomyosarcoma of bone: A study of five cases
Author(s) -
Angervall Lennart,
Berlin Örjan,
Kindblom LarsGunnar,
Stener Bertil
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800901)46:5<1270::aid-cncr2820460531>3.0.co;2-3
Subject(s) - hypervascularity , van gieson's stain , leiomyosarcoma , medicine , trichrome stain , pathology , anatomy , trichrome , basal lamina , lesion , h&e stain , ultrastructure , immunohistochemistry
Five canes of leiomyosarcoma of bone are described. The patients, 3 men and 2 women, ranged in age from 24 to 74 years. Four of the five tumors were located in the distal half of the femur. Radiographically, all tumors presented as purely osteolytic lesions. Angiography, performed in 3 cases, revealed hypervascularity and the presence of irregular, tortuous vessels at the site of the lesion in 1, but not in 2 others. Histologically, the five tumors showed features characteristic of leiomyosarcomas. The most prominent features were blunt‐ended, cigar‐like, chromatin‐rich nuclei in elongated acidophilic cells arranged in bundles which intersected each other at wide angles. The importance of trichrome stains, such as van Gieson stain, for the recognition of leiomyosarcomas is emphasized. Electron microscopic examination, performed in 3 cases, showed as the most prominent features spindle‐shaped cells in parallel arrangement containing abundant myofilaments with elongated densities, pinocytotic vesicles, and basal lamina structures.