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Successful therapy of an ACTH‐producing gastric carcinoid APUD tumor: Report of a case and review of the literature
Author(s) -
Marcus Fred S.,
Friedman Michael A.,
Callen Peter W.,
Churg Andrew,
Harbour John
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800901)46:5<1263::aid-cncr2820460530>3.0.co;2-z
Subject(s) - medicine , adrenocorticotropic hormone , gastroenterology , endocrinology , hormone
A case of a patient with a metastatic ACTH (adrenocorticotrophic hormone)‐producing gastric carcinoid APUD (amine precursor uptake and decarboxylation) tumor is presented. The patient presented with Cushing's syndrome and very high levels of ACTH. The Cushing's syndrome was controlled medically, and when the patient deteriorated clinically she received treatment with a combination of BCNU, adriamycin, and ftorafur. She responded dramatically with marked clinical improvement and normalization of plasma ACTH levels. The current status of the APUD cell concept is discussed, with its overall implications for treatment of this group of malignancies.