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Evaluation of fluorescence polarization of human blood lymphocytes (SCM test) in the diagnosis of cancer
Author(s) -
Schnuda N. D.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800901)46:5<1164::aid-cncr2820460515>3.0.co;2-m
Subject(s) - medicine , malignant disease , stimulation , antigen , disease , cancer , pathology , immunology
Fluorescence polarization was performed on 82 individuals: 32 patients with malignant diseases, 30 apparently healthy individuals, and 20 patients with nonmalignant diseases. The blood lymphocytes from these cases were isolated and challenged with cancer basic protein (CaBP). Stimulation occurred in the majority of the cases of malignant disease (27 of 32). The 30 apparently healthy individuals showed no response to CaBP. Of the 20 patients with nonmalignant diseases, 18 showed no stimulation by the antigen.