Premium
Urothelial susceptibility to tumor cell implantation influence of cauterization
Author(s) -
Soloway Mark S.,
Masters Steven
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800901)46:5<1158::aid-cncr2820460514>3.0.co;2-e
Subject(s) - cauterization , medicine , urothelial cancer , oncology , cancer research , pathology , cancer , bladder cancer
In an effort to determine whether transitional tumor cells will preferentially implant on the cauterized urothelial surface, a reproducible technique for cauterization of a portion of the murine bladder was established. This technique simulates a transurethral fulguration of a bladder tumor in humans. Transplantable tumor cells (1 x 10 6 ) were placed transurethrally into the bladder of 50 mice. Twenty‐five of these mice each had a portion of their bladder cauterized prior to insertion of tumor cells. Implantation with subsequent tumors occurred in 54% of mice with cauterization, in contrast to 12% of mice with an intact urothelial surface (P < 0.005). Intravesical thio‐tepa, mitomycin C, and cis‐platinum were capable of significantly reducing the incidence of implantation. These results suggest that seeding may be a contributing factor to the high recurrence rate following endoscopic resection or fulguration of bladder tumors and that intravesical chemotherapy initiated shortly after surgery may reduce the incidence of implantation.