Premium
Pancreatic‐polypeptide‐producing apudoma of the liver
Author(s) -
Warner Thomas F. C. S.,
Seo In Sook,
Madura James A.,
Polak Julia M.,
Pearse A. G. E.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800901)46:5<1146::aid-cncr2820460512>3.0.co;2-r
Subject(s) - pancreatic polypeptide , medicine , gastrin , tumor cells , bombesin , enteroendocrine cell , pathology , endocrine system , neoplasm , pancreatic tumor , pancreas , antibody , hormone , glucagon , secretion , cancer research , pancreatic cancer , immunology , cancer , receptor , neuropeptide
A large hepatic neoplasm excised from a 62–year‐old man resembled a carcinoid tumor. No endocrine syndrome was present and an alternative primary source of tumor was not found, despite an intensive search. The tumor cells were classified according to the type of electron‐dense granules present: ACTH, gastrin (G), bombesin (P), and pancreatic polypeptide (PP) type granules were identified, Immunofluorescent staining with antibodies to several polypeptide hormones detected PP‐containing tumor cells only. This rare tumor is therefore a PP‐apudoma; possibly of intrahepatic bile duct origin.