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Identification of breast cancer patients with high risk of early recurrence after radical mastectomy: III. Steroid hormones measured in urine
Author(s) -
Segaloff Albert,
Hankey Benjamin F.,
Carter Anne C.,
Bundy Brian,
Masnyk Ihor J.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800901)46:5<1087::aid-cncr2820460502>3.0.co;2-o
Subject(s) - medicine , urine , breast cancer , hormone , steroid , mastectomy , modified radical mastectomy , oncology , cancer
The relationship of the levels of selected urinary steroid metabolites to breast cancer recurrence after radical mastectomy was studied. An analysis of variance of the steroid measurements suggested that the measurements standardized to per gram of creatinine were the appropriate measure to use in exploring these relationships. No significant associations were found for premenopausal patients; however, for postmenopausal patients, low levels of total 17‐ketosteroids were associated with a reduced two‐year recurrence‐free rate whereas low and high levels of OHA and high levels of total estrogens were associated with a relatively high two‐year recurrence‐free rate. Because of the large number of significance tests performed and the lack of consistent patterns, it is questionable whether the observed associations are of any importance. Including these steroid quantities in a multivariate regression model along with previously determined clinical prognostic factors indicated that the steroid determinations were the least important variables and did not make a significant contribution to the fit of the model.