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Activation of nevi in patients with malignant melanoma
Author(s) -
Tucker Stephen B.,
Horstmann Joseph P.,
Hertel Bruce,
Aranha Gerard,
Rosai Juan
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800815)46:4<822::aid-cncr2820460430>3.0.co;2-p
Subject(s) - melanoma , medicine , lymph , pathology , atypia , nevus , dermatology , cancer research
Activation of melanocytic nevi from patients with malignant melanoma is documented microscopically. Features of activation include marked junctional activity, lack of lateral margination of junctional melanocytic activity, and‐to a lesser degree‐increased pigment production, inflammation, mitotic activity, and cytologic atypia. The changes are most pronounced in nevi from the same lymph drainage region as the malignant melanoma, suggesting a local activating factor. The presence of marked junctional activity in these lesions and the occurrence of these changes in nevi of patients with clinical Stage I malignant melanomas provide evidence that these lesions do not represent metastases.