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Spinal melanotic clear‐cell sarcoma: A light and electron microscopic study
Author(s) -
Parker John B.,
Marcus Peter B.,
Martin James H.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800815)46:4<718::aid-cncr2820460414>3.0.co;2-1
Subject(s) - basal lamina , pathology , schwannoma , medicine , electron microscope , sarcoma , ultrastructure , context (archaeology) , anatomy , clear cell sarcoma , biology , paleontology , physics , optics
We report a melanotic spindle‐cell tumor that arose from a thoracic spinal nerve root and metastasized to both lungs. The bulk of the tumor consisted of glycogen‐rich clear cells and bore a striking resemblance on light and electron microscopy to at least one variant of the clear‐cell sarcoma of tendons and aponeuroses. The presence of schwannoma‐like areas noted in the primary tumor on light microscopy and the formation of a highly developed basal lamina noted on ultrastructural examination suggest that the tumor may be a partially dedifferentiated malignant melanotic schwannoma. This tumor is discussed in the context of a simple histogenetic classification of melanotic tumors.