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Adenocarcinoma of the colon with choriocarcinoma in its metastases
Author(s) -
Park C. H.,
Reid J. D.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800801)46:3<570::aid-cncr2820460325>3.0.co;2-y
Subject(s) - choriocarcinoma , adenocarcinoma , pathology , totipotent , medicine , chorioepithelioma , giant cell , cellular differentiation , cancer , biology , biochemistry , gene
A 49‐year‐old woman died from metastases from a colon carcinoma. This was predominantly an ordinary tubular adenocarcinoma but it included areas of much less differentiated appearance with giant cells, while the hepatic and pulmonary metastases were poorly differentiated and contained choriocarcinoma, as established by means of morphologic and immunocytochemical examination. The choriocarcinoma appeared to be due to metaplasia within the carcinomatous tissue. This and other similar cases of mixed tumors suggest that unexpected trophoblastic differentiation may result from aberrant differentiation of locally proliferating cells, rather than originating in ectopic germ cells or in foci of embryonic totipotent cells. Implications for possible origin and for classification of tumors are briefly discussed. Cancer 46:570–575, 1980.