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Smooth‐muscle antibodies in children with neuroblastoma
Author(s) -
Zauli Daniela,
Bianchi Francesco Bianco,
Gardelli Tullio,
Volta Umberto,
Lenzi Marco,
Mancini Antonia Francesca,
Pisi Emilio
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800801)46:3<497::aid-cncr2820460313>3.0.co;2-l
Subject(s) - sma* , neuroblastoma , myosin , medicine , immunofluorescence , antibody , heavy meromyosin , actin , pathology , antigen , meromyosin , cancer , immunology , biology , microbiology and biotechnology , myosin light chain kinase , myosin head , cell culture , genetics , mathematics , combinatorics
Smooth‐muscle antibodies (SMA) were detected in 16 of 18 (89%) children with neuroblastoma and in 43 of 172 (25%) pediatric hospital patients without malignancies. The SMA were mainly of the IgG class. The most common immunofluorescence pattern was SMA‐V (vessel) and titers did not exceed 1:160. Absorption and immunodiffusion tests with actin (from rabbit skeletal muscle) showed that the SMA associated with neuroblastoma are mainly directed against actin, although different antigen specificities (myosin, meromyosin) are probably involved in some cases. In both chronic active hepatitis and neuroblastoma, SMA would represent a specific response to intracellular contractile proteins (mainly actin) induced by tissue damage. A feedback role in controlling cellular proliferation has been postulated for experimentally raised SMA. This would be relevant in cases of malignancy. Cancer 46:497–499, 1980.