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Impaired cell‐mediated immunity function in thyroid cancer
Author(s) -
Liaw KoungYi,
ChangChien Yao,
Chen YaoChang,
Deng JauShyong
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800715)46:2<285::aid-cncr2820460211>3.0.co;2-3
Subject(s) - medicine , immunity , thyroid cancer , cellular immunity , cell mediated immunity , antibody , cancer , peripheral blood , endocrinology , immunology , immune system
Immunological parameters were studied in 31 patients with thyroid cancer. Serum immunoglobulin levels, T and B cell percentages in peripheral blood, showed no significant difference as compared with those of control group. The blastogenesis with phytohemagglutinin P (PHA) was significantly reduced, especially, in those having larger tumor size or metastasis or in those over age 60. The positive rate of skin test with purified‐protein‐derivative (PPD) and Streptokinase‐Streptodornase (SK‐SD) was also markedly reduced. The impaired blastogenesis of lymphocyte and reduced positive rate of skin test in those cancer patients suggested that the cell‐mediated immunity function, in spite of adequate count of T‐cell, was impaired.