Premium
Chemotherapy of extensive large cell and adenocarcinoma of the lung. A randomized trial in 210 patients
Author(s) -
Vincent R. G.,
Mehta C. R.,
Tucker R. D.,
Mountain C. F.,
Cohen M.,
Wilson H. E.,
Vogel C.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800715)46:2<256::aid-cncr2820460206>3.0.co;2-q
Subject(s) - procarbazine , medicine , randomized controlled trial , adenocarcinoma , lung cancer , oncology , lomustine , chemotherapy , vincristine , cancer , cyclophosphamide
Two hundred ten patients with advanced adenocarcinoma of the lung were entered into a two‐arm randomized trail. Cytoxan + CCNU + methotrexate was compared to Adriamycin and procarbazine. The tumor response to CCM was significantly higher than the tumor response to Adriamycin and procarbazine. No significant difference existed between the two treatments with respect to survival. Initial performance status, weight loss prior to therapy, and response to therapy were all found to be significant prognostic factors. Median survival time relative to responders in both treatment groups was 31.7 weeks and 15.8 weeks for non‐responders.