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Subpopulations of human T lymphocytes VI. Analysis of cell markers in acute lymphoblastic leukemia with special reference to Fc receptor expression on E‐rosette‐forming blasts
Author(s) -
Beck J. D.,
Haghbin M.,
Wollner N.,
Mertelsmann R.,
Garrett T.,
Koziner B.,
Clarkson B.,
Miller D.,
Good R. A.,
Gupta S.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800701)46:1<45::aid-cncr2820460111>3.0.co;2-m
Subject(s) - lymphoblast , terminal deoxynucleotidyl transferase , receptor , null cell , medicine , rosette (schizont appearance) , precursor cell , leukemia , immunology , acute lymphocytic leukemia , complement receptor , cell , lymphoblastic leukemia , microbiology and biotechnology , biology , cell culture , complement system , antibody , tunel assay , immunohistochemistry , biochemistry , genetics
A variety of surface markers, terminal deoxynucleotidyl transferase (TdT) activity, morphologic appearance, and cytochemical composition were studied in a group of 16 patients (13 children, 3 adults) with acute lymphoblastic leukemia (ALL). In 9 children, no surface markers were detected on lymphoblasts (null‐type ALL). Leukemic blasts of 4 children formed E‐rosettes. These E‐rosette‐forming blasts from childhood ALL, and E‐rosette‐forming lymphoblasts from 3 adult patients with ALL, were studied for the presence of Fc receptors. Of the leukemic blasts from these 7 patients, 2–76% expressed receptors for IgG Fc. Only 3 of 7 patients showed 9–42% receptors for IgM Fc. In addition, complement receptors were investigated in 6 of those 7 patients with T‐cell ALL. Complement receptors were detected on 9–70% of the E rosette forming blasts from all 6 patients. TdT activity was elevated in T‐cell ALL and in children with null‐type ALL. The heterogeneity of Fc receptor expression on leukemic blasts in these patients demonstrates a malignant proliferation of T cells in different stages of differentiation or maturation. This observation might be helpful in subclassifying T‐cell leukemias with regard to prognosis and the response to therapy. Cancer 46:45–49, 1980.