Premium
Intracytoplasmic fibrillary inclusions in bronchial carcinoid
Author(s) -
AlvarezFernandez E.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800701)46:1<144::aid-cncr2820460123>3.0.co;2-j
Subject(s) - trichrome stain , pathology , cytoplasmic inclusion , golgi apparatus , inclusion bodies , stain , cytoplasm , anatomy , chemistry , medicine , biology , staining , microbiology and biotechnology , immunohistochemistry , endoplasmic reticulum , biochemistry , escherichia coli , gene
A case of bronchial carcinoid with filamentous aggregates is described. The cytoplasmic inclusions were clearly demonstrated by means of Masson's trichrome stain in Bouin's fixed tissue, and the neoplastic cells showed a spontaneous green fluorescence with ultraviolet light. Electron microscopic examination showed that the inclusion bodies were composed of aggregates of filaments measuring 10Å. They were located in the juxtanuclear region in close relation with mitochondria and the cisternae of the Golgi system. There were many neurosecretory granules inside the aggregates of filaments, some showing alterations in the dense core. From this data, we concluded that the aggregates seemed to represent an active rather than an involutional phenomenon and that their relation with hypoxemia and humoral influences needs further study. Cancer 46:144–151, 1980.