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Burkitt's lymphoma presenting as acute leukemia (Burkitt's lymphoma cell leukemia). Report of two cases in Israel
Author(s) -
Prokocimer Miron,
Matzner Yaacov,
BenBassat Hannah,
Polliack Aaron
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800601)45:11<2884::aid-cncr2820451128>3.0.co;2-l
Subject(s) - medicine , lymphoma , burkitt's lymphoma , pathology , bone marrow , leukemia , chemotherapy , acute leukemia , immunology
Two rare cases of Burkitt's lymphoma presenting as acute leukemia are described. Both patients had typical features of Burkitt's lymphoma with rapidly growing, extranodal tumor masses which were multifocal. The blasts infiltrating the bone marrow and peripheral blood showed cytologic, cytochemical, immunologic, and ultrastructural features of Burkitt's tumor cells. The cells had B‐cell markers but lacked the EBV‐DNA genome and had multiple microvilli as seen by means of scanning electron microscopy. In both cases, the disease was resistant to chemotherapy and rapidly fatal, despite the fact that complete remissions of short duration were obtained.