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125 Iodine prostate implants for recurrent carcinomas after external beam irradiation: Preliminary results
Author(s) -
Goffinet Don R.,
Martinez Alvaro,
Freiha Fuad,
Pooler Donna M.,
Pistenma David A.,
Cumes David,
Bagshaw Malcolm A.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800601)45:11<2717::aid-cncr2820451104>3.0.co;2-#
Subject(s) - medicine , prostate , urology , implant , carcinoma , fistula , prostate cancer , urinary incontinence , nuclear medicine , surgery , cancer
Fourteen patients with locally recurrent prostate carcinomas after external beam irradiation received 125 I seed implants at Stanford between 1975 and 1979. Clinical local control has been obtained in 11 of the 14 patients for follow‐up periods of 6 to 36 months. Eight remain without evidence of disease, but 2 of the 3 patients whose pelvic lymph nodes were involved by carcinoma have developed distant metastases. Complications, consisting of either cystoproctitis, urinary incontinence, or the development of a vesicorectal fistula occurred in 4 of the 14 patients. These complications were noted only in those patients who had implantation of high intensity 125 I seeds (>0.50 mCi) into large prostatic volumes (>50 cc). No complications occurred in patients who received lower intensity 125 I seed implants in smaller prostatic volumes. We conclude that 125 I seed implants may be used in a second attempt to obtain local control after a local relapse following external beam irradiation, if the use of high intensity 125 I sources and/or the implantation of large prostate volumes are avoided.