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Bacteremic infection and malnutrition in patients with solid tumors. Investigation of host defense mechanisms
Author(s) -
Phair John P.,
Riesing Kathleen S.,
Metzger Eileen
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800515)45:10<2702::aid-cncr2820451036>3.0.co;2-4
Subject(s) - medicine , bacteremia , neutropenia , malnutrition , abnormality , urinary system , lymphocyte , cancer , gastrointestinal tract , immunology , gastroenterology , pathology , antibiotics , chemotherapy , biology , microbiology and biotechnology , psychiatry
Eighty‐five patients with solid tumors without neutropenia were studied in order to determine host characteristics associated with bacteremic infection. Twenty patients without neoplastic disease who had bacteremia served as controls. Bacteremia frequently occurred in patients with tumors of the gastrointestinal and urinary tract, who were over 51 years of age, and had evidence of malnutrition. Peripheral blood lymphocyte dysfunction in vitro was commonly noted in infected patients with cancer. Polymorphonuclear leukocyte (PMNL) dysfunction was common in older bacteremic patients with and without cancer. The PMNL abnormality appeared to be cellular, it was not corrected with use of pooled normal serum, and was manifested by poor uptake of the assay organisms. S. aureus 502A.