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Hepatic veno‐occlusive disease due to DTIC
Author(s) -
Asbury Robert F.,
Rosenthal Susan N.,
Descalzi Mario E.,
Ratcliffe Rita L.,
Arseneau James C.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800515)45:10<2670::aid-cncr2820451031>3.0.co;2-l
Subject(s) - medicine , fulminant hepatic failure , autopsy , fulminant , hepatic veno occlusive disease , disease , melanoma , necrosis , chemotherapy , cause of death , surgery , pathology , transplantation , liver transplantation , cancer research , hematopoietic stem cell transplantation
A case of fulminant hepatic failure leading to death in a patient receiving DTIC for metastatic melanoma is presented. Autopsy revealed widespread centrilobular necrosis secondary to a veno‐occlusive process. There was no evidence of a similar process in other organs, and common causes of similar pathology were ruled out. It is likely that in this patient the hepatic failure was due to DTIC alone. Similar cases have been reported in patients receiving other chemotherapeutic agents. Physicians using these drugs should be aware of this side‐effect of therapy, since it is often fatal.