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Familial clustering of malignant mesothelioma
Author(s) -
Risberg Björn,
Nickels Juha,
Wågermark Jan
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800501)45:9<2422::aid-cncr2820450930>3.0.co;2-z
Subject(s) - mesothelioma , asbestos , medicine , heredity , incidence (geometry) , pathology , family aggregation , oncology , disease , genetics , materials science , physics , biology , optics , metallurgy
A family with a remarkable aggregation of malignant mesothelioma is described. The father, 3 brothers, and a sister all died of the condition. The family and epidemiologic histories are reviewed. Random occupational asbestos exposure in the building industry probably occurred in 4 of the 5 cases. All of the patients were smokers. There is a low incidence of malignant mesothelioma in the area where they resided. These observations suggest that over and above the smoking and asbestos exposure, heredity may be an important predisposing factor in the genesis of this tumor.