Premium
Mucin‐producing adenocarcinomas and nonbacterial thrombotic endocarditis. Pathogenetic role of tumor mucin
Author(s) -
Min KyungWhan,
Gyorkey Ferene,
Sato Clifford
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800501)45:9<2374::aid-cncr2820450923>3.0.co;2-j
Subject(s) - mucin , medicine , pathology , thrombosis , endocarditis
The clinicopathologic data for 5 patients who died of nonbacterial thrombotic endocarditis (NBTE) and disseminated thrombosis and multiple infarcts associated with mucin‐producing adenocarcinomas were presented. Histochemical studies on the valvular vegetations and thrombi revealed that histochemically stainable mucinous substance was an integral part. In 1 patient, circulating mucinous substance was found prior to the development of NBTE and disseminated thrombosis, and the identical mucinous substance was found in the tumor tissue, indicating a possible pathogenetic role of tumor mucin in NBTE‐associated mucin‐producing adenocarcinomas. Our observations and reports of others suggest that intravascular mucin may be responsible for the clinical syndromes of mucinous malignancies, venous thrombosis, and NBTE with emboli.