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Cytotoxic‐induced fulminant hyperpyrexia
Author(s) -
F. David D.,
Isbister James P.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800501)45:9<2249::aid-cncr2820450905>3.0.co;2-6
Subject(s) - medicine , coagulopathy , cytotoxic t cell , fulminant , hypofibrinogenemia , daunorubicin , bleomycin , disseminated intravascular coagulation , acute myeloblastic leukemia , leukemia , gastroenterology , immunology , chemotherapy , pathology , fibrinogen , biochemistry , chemistry , in vitro
Two cases of fulminant hyperpyrexia induced by cytotoxic agents (bleomycin in a patient with lymphoma, and daunorubicin in a patient with acute myeloblastic leukemia) are presented. Each patient had a fever greater than 42°C, with a shock‐like reaction and coma. Evidence of disseminated intravascular coagulopathy developed in the patient with bleomycin‐induced hyperpyrexia and she died 24 hours afterwards. The pathogenesis and management of hyperpyrexial reactions to cytotoxic drugs are discussed.