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Long‐term survival in acute leukemia in Japan A study of 304 cases
Author(s) -
Kawashima Kohei,
Suzuki Hisamitsu,
Yamada Kazumasa,
Kato Yukio,
Morishima Yasuo,
Takeyama Hideo,
Kobayashi Masahide
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800415)45:8<2181::aid-cncr2820450829>3.0.co;2-9
Subject(s) - medicine , leukemia , pediatrics , acute promyelocytic leukemia , acute myeloblastic leukemia , complete remission , acute lymphocytic leukemia , lymphoblastic leukemia , chemotherapy , biochemistry , retinoic acid , chemistry , gene
In a national survey of five‐year survivors with acute leukemia, 233 of 304 cases were children under 14 years of age and 71 were adults. There were 107 myeloblastic, 10 promyelocytic, 142 lymphocytic, and 37 undifferentiated leukemias. Forty‐five cases at age 3 represented the peak. These long‐term survivors have shown a yearly increase in number. In 1972, the number of childhood ALL cases reached 38 with no great changes in ANLL cases. With respect to prognosis among long‐term survivors, it seemed that neither type of leukemia nor age at diagnosis were factors influencing the future survival. CNS relapse occurring before the third year was an unfavorable complication for a prognosis beyond five years. Only 8 patients died of leukemia among 155 patients who reached five years in their initial complete remission; 49 of 90 patients who had relapse within five years after diagnosis died of leukemia. From these findings, it seems, very important to follow patients for five years in their initial complete remission.