Premium
Bone marrow transplantation for the therapy of refractory adult T cell acute lymphoblastic leukemia
Author(s) -
Garrett T. J.,
Grossbard E.,
Hopfan S.,
Koziner B.,
Clarkson B. D.,
Good R. A.,
O'Reilly R.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800415)45:8<2006::aid-cncr2820450804>3.0.co;2-m
Subject(s) - medicine , cyclophosphamide , surgery , refractory (planetary science) , total body irradiation , transplantation , leukemia , chemoradiotherapy , bone marrow , acute leukemia , radiation therapy , gastroenterology , chemotherapy , physics , astrobiology
Two adult patients with T cell acute lymphoblastic leukemia (ALL) received an intensive multiagent therapeutic regimen and failed to enter remission. Following cytoreduction with cyclophosphamide (60 mg/kg × 2) and total body irradiation (1000 rads) they underwent bone marrow transplantation. One patient received marrow from his identical twin brother and the other from his HLA‐matched sister. Both patients promptly went into remission. The identical twin recipient is alive and free of disease at 20+ months, but the allogeneic patient died of P. carinii pneumonia at eight months with no evidence of leukemia. These results suggest that even some refractory patients whose disease has multiple negative prognostic features may respond to pretransplant chemoradiotherapy and attain a clinically useful complete remission. Additional patients with longer follow‐up will be necessary before the curative potential of bone marrow transplantation in T cell ALL can be assessed.