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Hepatic involvement in the cutaneous T‐cell lymphomas. Results of percutaneous biopsy and peritoneoscopy
Author(s) -
Huberman Mark S.,
Bunn Paul A.,
Matthews Mary J.,
Ihde Daniel C.,
Gazdar Adi F.,
Cohen Martin H.,
Minna John D.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800401)45:7<1683::aid-cncr2820450727>3.0.co;2-c
Subject(s) - medicine , biopsy , liver biopsy , pathology , lymphoma , cutaneous t cell lymphoma , mycosis fungoides
Forty‐three patients with cutaneous T‐cell lymphomas (mycosis fungoides and the Sezary syndrome) underwent routine staging procedures to assess extent of disease prior to therapy. Evaluation of the liver included physical examination, liver function tests, 99m Tc‐liver‐spleen scans, percutaneous liver biopsy, and peritoneoscopy with multiple liver biopsies. Seven patients (16%) had biopsy‐documented hepatic lymphoma, histologically defined as focal aggregates of atypical convoluted lymphocytes in portal zones or hepatic lobules. The liver was the most frequently involved visceral site. Involvement of peripheral blood, leukocytosis, and generalized erythroderma were significantly associated with hepatic lymphoma. Biopsy examination was the only accurate method of detecting hepatic involvement, and peritoneoscopy with multiple biopsies appeared to be more sensitive than a single percutaneous biopsy, since the yield of positive biopsies increased from three to seven. In order to better understand the natural history of the cutaneous T‐cell lymphomas and the relation of hepatic involvement to survival, histologic evaluation of the liver in patients with the cutaneous lymphomas should be carried out prior to therapy.