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Malignant schwannoma. A light microscopic and ultrastructural study
Author(s) -
Chen Karl T. K.,
Latorraca Rocco,
Fabich Douglas,
Padgug Andrew,
Hafez G. Reza,
Gilbert Enid F.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800401)45:7<1585::aid-cncr2820450712>3.0.co;2-p
Subject(s) - ultrastructure , schwannoma , pathology , nerve sheath tumor , anatomy , sarcoma , neurofibroma , basement membrane , medicine , tumor cells , soft tissue , schwann cell , biology , neurofibromatosis , cancer research
The light microscopic and ultrastructural features of 3 cases of malignant schwannoma were studied and compared with those of other types of soft‐tissue sarcoma. The tumor in 1 of these cases originated in an intercostal nerve and was composed of compactly arranged spindle‐shaped tumor cells. The other 2 cases showed osteogenic areas in addition to exhibiting prominent nuclear palisading, focal myxoid changes, and a rosette‐like arrangement of tumor cells. The tumor in 1 of these latter cases occurred at the site of a preexisting neurofibroma. The Schwann cell origin of these tumors is strongly supported by the ultrastructural findings of basement membranes and conspicuous intercellular junctions in all 3 cases and dense‐core granules in 1.