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Successful treatment of recurrent primary central nervous system lymphoma with high‐dose methotrexate
Author(s) -
Ervin Thomas,
Canellos George P.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800401)45:7<1556::aid-cncr2820450707>3.0.co;2-b
Subject(s) - medicine , methotrexate , primary central nervous system lymphoma , central nervous system , lymphoma , chemotherapy , disease , surgery , pathology
Primary central nervous system (CNS) lymphoma is a rare disease, usually resistant to therapy. In the case presented, a 51‐year‐old woman with documented primary cerebellar CNS lymphoma, lymphoplasmacytoid type, underwent surgical resection and whole brain irradiation and then recurred within the CNS. Treatment with 17 courses of high‐dose methotrexate resulted in complete disappearance of the tumor and clearing of all neurologic signs and symptoms. She is now free of disease 12 months after beginning chemotherapy. The potential usefulness of systemic antimetabolites for treatment of CNS lymphoma, primary or disseminated, is discussed.