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Prognostic factors in Burkitt's lymphoma importance of total tumor burden
Author(s) -
Magrath Ian,
Lee Young Jack,
Anderson Tom,
Henle Werner,
Ziegler John,
Simon Richard,
Schein Philip
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800315)45:6<1507::aid-cncr2820450634>3.0.co;2-d
Subject(s) - medicine , uric acid , lymphoma , stage (stratigraphy) , lactic dehydrogenase , titer , gastroenterology , lactate dehydrogenase , lactic acid , tumor stage , burkitt's lymphoma , pathology , immunology , oncology , cancer , enzyme , virus , biology , biochemistry , genetics , bacteria , paleontology
In 42 patients with African Burkitt's lymphoma, we have studied biochemical and clinical correlations with prognosis. Clinical stage and anti‐EA titer were the best predictive factors, but lactic dehydrogenase (LDH) and uric acid (UA) concentrations also correlated with stage and prognosis, whereas lactic acid (LA), which was significantly elevated in Stage D, did not significantly correlate with prognosis or with LDH and UA levels. All of these factors with the possible exception of LA reflect the total body burden of tumor. We conclude that the tumor burden is the single most important prognostic factor in Burkitt's lymphoma, and that this is reflected directly by LDH and UA concentrations, and probably indirectly by anti‐EA titer.