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Comparison of tamoxifen and hypophysectomy in breast cancer treatment
Author(s) -
Kiang David T.,
Frenning Daniel H.,
Vosika Gerald J.,
Kennedy B. J.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800315)45:6<1322::aid-cncr2820450609>3.0.co;2-k
Subject(s) - medicine , tamoxifen , hypophysectomy , breast cancer , oncology , cancer , hormone
The effectiveness of hypophysectomy and tamoxifen in treating advanced breast cancer was compared in a randomized study of 26 patients who had responded to prior oophorectomy or additive hormonal therapy. When patients failed to respond or relapsed from tamoxifen or hypophysectomy, the therapy was crossed over. In this designed sequence, the rate and duration of response observed with tamoxifen or hypophysectomy used as the first regimen were comparable. The results suggest that tamoxifen is effective in the posthypophysectomy phase and the sequence of hypophysectomy followed by tamoxifen in hormone‐dependent breast cancer is preferable to achieve a maximal control of the disease.