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Pulmonary fibrosis following low‐dose 1,3‐bis (2‐chloro‐ethyl)‐1‐nitrosourea (BCNU) therapy
Author(s) -
Melato Mauro,
Tuveri Guido
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800315)45:6<1311::aid-cncr2820450607>3.0.co;2-u
Subject(s) - medicine , nitrosourea , carmustine , pulmonary fibrosis , lomustine , fibrosis , pharmacology , chemotherapy , etoposide , vincristine , cyclophosphamide
Two women, 65 and 55 years old, with metastatic malignant melanoma, were treated with low doses of BCNU for a short period (six and three months, total dose 2500 and 2000 mg). Both patients developed pulmonary fibrosis, which was visible in postmortem examination. In the first woman, lesion, development was so widespread as to be considered responsible for death. Because chest x‐ray before treatment was not abnormal, we consider BCNU capable of inducing the lesion.