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Father‐son testicular malignancy does genetic anticipation occur?
Author(s) -
Raghavan Derek,
Jelihovsky Tatiana,
Fox Richard M.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800301)45:5<1005::aid-cncr2820450529>3.0.co;2-0
Subject(s) - malignancy , anticipation (artificial intelligence) , seminoma , medicine , testicular cancer , embryonal carcinoma , testicular germ cell tumor , cancer , pathology , biology , genetics , cellular differentiation , chemotherapy , artificial intelligence , computer science , gene
Testicular malignancy in a father and son is reported. The father had sequential bilateral seminomas while the son had embryonal cell carcinoma and seminoma. Reported cases of father‐son testicular malignancy are reviewed and a predominance of seminomas in the fathers is apparent while the sons' tumors are highly malignant teratomas, choriocarcinomas and embryonal cell carcinomas. The possibility of genetic anticipation in father‐son testicular malignancy is discussed.