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Influence of estrogen receptor status on response of metastatic breast cancer to aminoglutethimide therapy
Author(s) -
Lawrence Bellarmine V.,
Lipton Allan,
Harvey Harold A.,
Santen Richard J.,
Wells Samuel A.,
Cox Charles E.,
White Deborah S.,
Smart Emma K.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800215)45:4<786::aid-cncr2820450429>3.0.co;2-x
Subject(s) - medicine , aminoglutethimide , breast cancer , estrogen receptor , metastatic breast cancer , complete response , cancer , estrogen , oncology , progesterone receptor , gastroenterology , urology , endocrinology , chemotherapy , aromatase
Aminoglutethimide (AG) is an effective chemical ablative form of therapy for metastatic breast cancer in postmenopausal women. Estrogen receptor (ER) status in breast cancer is useful in predicting the response to the hormonal treatments. Of 134 postmenopausal metastatic breast cancer patients treated with AG, ER analysis was done in 63 patients, 52 of whom are now evaluable. ER biopsy was performed prior to AG therapy in 61 patients, but the results were not known to the investigators. Cancer 45:786‐791, 1980. ER value ⩽10 fmol/mg cytosol protein was considered ER positive (ER+), 4–9.9 fmol/mg borderline, and <4 fmol/mg ER negative (ER‐). In 38 ER+ patients, objective response rate was 50% (three complete response, 16 partial response) and eight stabilization. Median duration of objective response was 15 months. Forty‐three percent of the patients with borderline estrogen receptor level responded objectively (three partial response) with the median duration of response eleven months. Fourteen percent of ER– patients responded objectively (one complete response). Hence the estrogen receptor level predicts response in ER+ and ER borderline patients treated with AG. Cancer 45:786‐791, 1980.