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Clinical experience with irradiation of inflammatory carcinoma of the breast with and without elective chemotherapy
Author(s) -
Barker Jerry L.,
Montague Eleanor D.,
Peters Lester J.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800215)45:4<625::aid-cncr2820450402>3.0.co;2-v
Subject(s) - medicine , chemotherapy , incidence (geometry) , mammary carcinoma , breast cancer , carcinoma , breast carcinoma , surgery , cancer , oncology , physics , optics
From 1948 to 1972, 69 patients with inflammatory carcinoma of the breast were treated with irradiation alone. Because of a 46% incidence of local‐regional failure, twice daily fractionated irradiation was given in 1972 to 11 patients; a decrease in local‐regional failures (27%) was achieved. From 1973 through December 1976, preirradiation multidrug chemotherapy was added to the twice daily fractionated irradiation of 31 patients. Analysis of all patients with a minimum two‐year follow‐up demonstrates that chemotherapy does not improve local‐regional control or freedom from disease rates, but does delay appearance of distant metastases. Cancer 45:625‐625‐629, 1980.