Premium
Surgical treatment of single brain metastasis: Factors associated with survival
Author(s) -
Galicich Joseph H.,
Sundaresan Narayan,
Arbit Ehud,
Passe Sharon
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800115)45:2<381::aid-cncr2820450232>3.0.co;2-j
Subject(s) - medicine , brain metastasis , metastasis , craniotomy , survival rate , radiation therapy , surgery , overall survival , cancer , survival analysis , oncology
The results of surgical excision of solitary intracerebral metastases followed by whole‐brain radiation therapy between 1972 and 1978 in a series of 78 patients were analyzed. The overall median survival of the series was 6 months with a 1‐year survival rate of 29%. Statistical analyses of the data revealed that patients who presented with a cerebral metastasis 1 year or more after diagnosis of the primary cancer had a significantly longer survival than those in whom the metastasis was detected within 1 year ( P <.04). Patients with mild or no neurological deficits at time of craniotomy had a longer median survival and a 1‐year survival of 44% ( P <.01). The presence of metastases at one or two other sites did not significantly affect overall survival except in those patients in whom the brain metastasis was detected more than 1 year after diagnosis of the primary tumor. Factors found to affect survival in this study may be useful in predicting survival of future patients similarly treated.