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Myeloproliferative disorder in a t(13q14q) carrier
Author(s) -
Goh KongOo,
Bauman Arthur W.,
Townes Philip L.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800115)45:2<327::aid-cncr2820450221>3.0.co;2-b
Subject(s) - chromosomal translocation , daughter , robertsonian translocation , peripheral blood , medicine , cytogenetics , myeloproliferative disorders , karyotype , bone marrow , genetics , pathology , biology , immunology , chromosome , evolutionary biology , gene
A Robertsonian balanced translocation of two D chromosomes was found in the bone marrow cytogenetic studies of a 70‐year‐old myeloproliferative disorder (MPD) woman. G‐banding studies showed the translocation involved a 13q14q. An identical balanced t(13q14q) chromosomal pattern was found in her peripheral blood 3 years before the diagnosis of MPD as part of an investigation involving her daughter's reproductive difficulties. Her daughter is also a t(13q14q) balanced translocation carrier. The finding of a t(13q14q) in MPD may be coincidental or it may be predisposing to the development of MPD. Additional studies may elucidate this controversy.