Premium
Estrogen receptor protein in malignant carcinoid tumor a report of 2 cases
Author(s) -
Keshgegian Albert A.,
Wheeler James E.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800115)45:2<293::aid-cncr2820450216>3.0.co;2-5
Subject(s) - estrogen receptor , estrogen , medicine , receptor , carcinoid tumors , endocrinology , estrogen related receptor alpha , estrogen receptor beta , derepression , cancer research , cancer , breast cancer , chemistry , biochemistry , gene , gene expression , psychological repression
Two cases of metastatic malignant carcinoid tumor in elderly women contained significant amounts of estrogen receptor (19 and 32 femtomoles/mg protein) as shown by Scatchard‐plot analysis of a dextran‐coated charcoal assay, inhibition of binding by an estrogen analog (67 and 63%) and high‐affinity binding (Kd = 6.8 and 2.6 × 10 −10 M). The demonstration of estrogen receptor in malignant carcinoid tumor expands the spectrum of non‐breast or non‐gynecologic neoplasms that contain the receptor. The significance of estrogen receptor in such tumors is uncertain; it may represent aberrant derepression of the gene for estrogen receptor protein in a malignant tumor.