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A case of AMMoL with 8/21 translocation and loss of the Y as probably secondary events
Author(s) -
Hustinx T. W. J.,
Burghouts J. T. M.,
Scheres J. M. J. C.,
Smits A. P. T.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800115)45:2<285::aid-cncr2820450214>3.0.co;2-6
Subject(s) - chromosomal translocation , karyotype , clone (java method) , medicine , cytogenetics , chromosome , bone marrow , complete remission , pathology , microbiology and biotechnology , cancer research , genetics , chemotherapy , biology , dna , gene
The clinical, hematological, and cytogenetic characteristics of a male patient with AMMoL are described. Before treatment a clone with the complex karyotype 45,X,del(7)(q32), t(8;21)(q22;q22) was present in the bone marrow. During partial remission induced by cytostatics, the percentage of normal cells increased, and a cell line having a 46,XY,del(7)(q32) karyotype was found. After four therapy courses, when remission was complete, only chromosomally normal cells were seen. The cytogenetic data suggest that in this case the 8/21 translocation and loss of the Y chromosome were only secondary events.