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Methotrexate in the treatment of penile carcinoma
Author(s) -
Sklaroff Robert B.,
Yagoda Alan
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800115)45:2<214::aid-cncr2820450203>3.0.co;2-k
Subject(s) - methotrexate , medicine , penis , carcinoma , epidermoid carcinoma , surgery , chemotherapy
Eight patients with epidermoid carcinoma of the penis received methotrexate, five with high‐dose methotrexate, 250–1500 mg/m 2 with citrovorum rescue Q 2–4 weeks, and three with low‐dose methotrexate, 0.5–3.0 mg/kg weekly. Three (38%) patients achieved a complete or partial remission which persisted for 11, 3 and 2 months, respectively. Methotrexate appears to be an active agent in the treatment of advanced penile cancer.