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Elevated contents of spermidine and spermine in the erythrocytes of cancer patients
Author(s) -
Uehara Noriyoshi,
Shirakawa Shigeru,
Uchino Haruto,
Saeki Yukikazu
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800101)45:1<108::aid-cncr2820450120>3.0.co;2-w
Subject(s) - spermidine , spermine , polyamine , medicine , cancer , biochemistry , high performance liquid chromatography , cancer cell , red blood cell , endocrinology , chemistry , chromatography , enzyme
Red blood cells (RBC) from 69 patients with advanced cancer and 37 healthy controls were subjected to polyamine determination by using high‐performance liquid chromatography. The polyamine contents in normal human RBC were spermidine 15.04 ± 3.63 nmol and spermine 8.82 ± 3.12 nmol per 10 10 RBC. Spermidine and spermine levels in RBC were elevated in patients with cancer (p < 0.005). Serial studies in seven patients with cancer indicated that both polyamines in RBC were reduced after successful surgery. Our data indicate that the determination of polyamine levels in RBC is clinically useful as a marker of disease activity in patients with cancer.