Premium
Acute myeloblastic leukemia developing in patients with mediastinal lymphoblastic lymphoma
Author(s) -
Kjeldsberg Carl R.,
Nathwani Bharat N.,
Rappaport Henry
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197912)44:6<2316::aid-cncr2820440647>3.0.co;2-6
Subject(s) - medicine , lymphoblastic lymphoma , bone marrow , acute myeloblastic leukemia , pathology , lymphoma , myeloid , autopsy , leukemia , myeloid leukemia , cancer research , immunology , immune system , t cell
Of three patients with mediastinal malignant lymphoma, lymphoblastic type, at the time of diagnosis one also had acute myeloblastic leukemia (AML), and the other two had blood and bone marrow findings indicative of acute lymphoblastic leukemia (ALL). The latter two patients developed the hematologic picture of AML less than eight months later. In all cases, AML was confirmed by cytochemical studies of peripheral blood and bone marrow cells. Autopsy of two of the patients revealed only AML. The myeloid nature of the proliferative cells was demonstrated with the naphthol‐ASD‐chloroacetate stain (NCA) on postmortem tissue sections. This study further supports the hypothesis of a common origin of neoplastic lymphoid and myeloid cells from pluripotent bone marrow stem cells.