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Alkaline phosphatase levels in osteosarcoma tissue are related to prognosis
Author(s) -
Levine Alan M.,
Rosenberg Steven A.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197912)44:6<2291::aid-cncr2820440643>3.0.co;2-s
Subject(s) - alkaline phosphatase , osteosarcoma , elevated alkaline phosphatase , medicine , phosphatase , pathology , enzyme , biology , biochemistry
Levels of alkaline phosphatase were measured in the primary tumor of 26 patients with osteosarcoma. One of seven patients with a tissue alkaline phosphatase level less than 0.6 μM/min/mg developed pulmonary metastases. In contrast, 16 of 17 patients with a tissue alkaline phosphatase level greater than 0.6 μM/min/mg developed pulmonary metastases. It thus appears that tissue alkaline phosphatase levels of primary osteosarcomas are strongly correlated with prognosis (p < .01).