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Hypercalcemia complicating childhood malignancies. A report of seven cases with some pathophysiological considerations
Author(s) -
Harguindey S.,
Decastro L.,
Barcos M.,
Getaz E. P.,
Henderson E. S.,
Freeman A.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197912)44:6<2280::aid-cncr2820440642>3.0.co;2-z
Subject(s) - medicine , pathophysiology , parathyroid hormone , metabolic disorder , cancer , homeostasis , endocrinology , calcium metabolism , secretion , calcium
A group of seven children with different malignant processes presenting with hypercalcemia was studied. Bone destruction, diffuse metabolic abnormalities, abnormal acid‐base homeostasis and recurrent hypercalcemia characterized these patients. A different mechanism leading to the production of hypercalcemia and/or bone destruction by cancer cells is considered. The results of this report suggest that parathyroid hormone production (P.T.H.) by the parathyroid glands is normal and that ectopic secretion of PTH or PTH‐like material is negligible in these cases.