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Somatostatinoma of the duodenum
Author(s) -
Kaneko Hiroshi,
Yanaihara Noboru,
Ito Seiki,
Kusumoto Yoshisuke,
Fujita Tsuneo,
Ishikawa Shinobu,
Sumida Toshiko,
Sekiya Masao
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197912)44:6<2273::aid-cncr2820440641>3.0.co;2-u
Subject(s) - duodenum , somatostatin , pancreas , radioimmunoassay , medicine , cytoplasm , pathology , endocrinology , biology , biochemistry
An adenocarcinoma of the second portion of the duodenum in a ear‐old male is presented. The patient was suffering from pain in the epigastrium. Immunofluorescent studies revealed that it consisted almost exclusively of cells with a distinctly positive somatostatin‐like immunoreactivity. Ultra‐structurally, the cytoplasm of the tumor cells had numerous large round granules (about 400 μm) with variable electron density. Most of these cells closely resembled the D cells normally seen in the duodenum and the islets of the pancreas, although a few argyrophil cells could be demonstrated by light microscopy. Radioimmunoassay of extracts of the tumor revealed a large amount of somatostatin (2260 pg/mg); substance P and VIP were detected also. Somatostatinoma has been known to occur in the pancreas, but this seems to be the first somatostatinoma found in the intestine.