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Disseminated coagulopathy in chronic myelomonocytic leukemia
Author(s) -
Gingrich Roger D.,
Burns C. Patrick
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197912)44:6<2249::aid-cncr2820440637>3.0.co;2-z
Subject(s) - medicine , monocytosis , chronic myelomonocytic leukemia , disseminated intravascular coagulation , coagulopathy , pathology , gastroenterology , bleeding diathesis , leukemia , acute myelomonocytic leukemia , coagulation , platelet , bone marrow , myelodysplastic syndromes
The clinical and laboratory features of nine patients with chronic myelomonocytic leukemia are described. Hepatic or splenic enlargement accompanied by an absolute monocytosis in an older patient with an elevated serum or urine lysozyme and serum vitamin B 12 levels were characteristic of the majority of patients in this series. No single clinical or laboratory finding was diagnostic for the disease. Most importantly, seven of nine patients had abnormal coagulation values; in two cases the abnormalities were consistent with disseminated intravascular coagulation and correlated with a hemorrhagic diathesis. It is concluded that patients with chronic myelomonocytic leukemia who have thrombocytopenia or a bleeding tendency should be evaluated for evidence of disseminated intravascular coagulation.