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Ultrastructural comparison of hepatoblastoma and hepatocellular carcinoma
Author(s) -
Horie Akio,
Kotoo Yasunori,
Hayashi Itsuro
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197912)44:6<2184::aid-cncr2820440631>3.0.co;2-u
Subject(s) - hepatoblastoma , hepatocellular carcinoma , glycogen , cytoplasm , ultrastructure , pathology , basal lamina , biology , medicine , microbiology and biotechnology , cancer research , endocrinology
The ultrastructural characteristics of fetal liver, two hepatoblastomas and two hepatocellular carcinomas were compared. Tumor cells of hepatoblastoma disclosed monotonous nuclei, poorly‐developed cytoplasmic membrane system, abundant free ribosomes and prominent glycogen granules. Those of hepatocellular carcinoma revealed comparatively pleomorphic nuclei, welldeveloped cytoplasmic membrane system, a few free ribosomes and numerous glycogen granules. Fetal liver showed monotonous nuclei, well‐developed RER, abundant free ribosomes and prominent glycogen granules. Young mesenchymal cells with well‐developed RER and continuous basal lamina surrounding the epithelial cells were detected in both cases of hepatoblastoma but not in those of hepatocellular carcinoma. Tumor cells of hepatoblastoma in a case showed intramitochondrial crystalloids and thick bundles of fibrils in the cytoplasm.