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Peripheral neuropathy associated with cis‐dichlorodiammineplatinum (II) treatment
Author(s) -
Hadley Dean,
Herr Harry W.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197912)44:6<2026::aid-cncr2820440610>3.0.co;2-1
Subject(s) - medicine , peripheral neuropathy , peripheral , sensory neuropathy , surgery , anesthesia , endocrinology , diabetes mellitus
Peripheral neuropathy developed in two cases of recurrent bladder carcinoma treated with Cis‐dichlorodiammineplatinum (II) (DDP) at a dose of 75 mg/m 2 IV every 3 weeks. The neuropathy appeared in both patients while they were achieving a subjective and objective response to DDP. The neuropathy was reversible in one patient. In the other patient, a disabling sensory neuropathy progressed despite cessation of therapy. The temporal relationship between the neurological symptoms and the administration of DDP implicate this drug as the possible causative agent in the peripheral neuropathy.