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Intra‐arterial BCNU therapy in the treatment of metastatic brain tumor from lung carcinoma. A preliminary report
Author(s) -
Yamada Kazuo,
Bremer Alfonso M.,
West Charles R.,
Ghoorah Jayah,
Park Hyung C.,
Takita Hiroshi
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197912)44:6<2000::aid-cncr2820440606>3.0.co;2-4
Subject(s) - medicine , lung , carcinoma , oncology , metastatic carcinoma , lung cancer , brain tumor , pathology
Nine patients with intracerebral metastasis from lung carcinoma were treated with intracarotid and intravertebral artery infusion of 1,3‐bis(2‐chloroethyl)‐1‐nitrosourea (BCNU). Four of these patients considered definite responders showed unequivocal clinical improvement and definite decreases in the size of tumors evaluated by neurologic examination, computerized tomographic (CT) scan and radionuclide brain scan (RBS). One patient's clinical condition stabilized with doubtful improvement of diagnostic tests (probable responder). The remaining four patients had further unfavorable progression of the clinical and scan findings and were clearly nonresponders. Complications were transient and included: local pain in the eye, orbit, and occipital‐nuchal area during infusion in 7 patients, focal seizure in 3 patients, mild confusion with disorientation in 2 patients, and nausea in 2 patients.