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The natural history of breast cancer patients with brain metastases
Author(s) -
Distefano Alfred,
Yap H. Yong,
Hortobagyi Gabriel N.,
Blumenschein George R.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197911)44:5<1913::aid-cncr2820440554>3.0.co;2-d
Subject(s) - medicine , natural history , breast cancer , brain metastasis , chemotherapy , surgery , metastasis , oncology , metastatic breast cancer , surgical resection , disease , cancer , radiology
One hundred one breast cancer patients with brain metastases (BM) were reviewed. The median survival from BM was 4.0 months. Seventy percent were receiving chemotherapy at the diagnosis of BM and 43% were showing a clinical response. Prolonged survival was seen in patients who underwent surgical resection, those with the brain as site of first metastasis, and those with a long free interval who survived the initial 5 months after BM. Long‐term survivors (>18 months from BM) demonstrated indolent disease by all parameters measured.