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Argyrophil cell carcinoma of the uterine cervix with ectopic production of acth, β‐MSH, serotonin, histamine, and amylase
Author(s) -
Matsuyama Mutsushi,
Inoue Takeo,
Ariyoshi Yutaka,
Doi Motoo,
Suchi Taizan,
Sato Tsuneko,
Tashiro Kannichiro,
Chihara Tsutomu
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197911)44:5<1813::aid-cncr2820440541>3.0.co;2-q
Subject(s) - medicine , histamine , adenocarcinoma , endocrinology , carcinoma , pancreas , pathology , cervix , anaplastic carcinoma , serotonin , cancer , receptor
The case of a 38‐year‐old female with primary argyrophil cell carcinoma of the uterine cervix is reported. Two years after operation the patient developed widespread metastases with typical Cushing's syndrome. Microscopically, the tumor consisted of solid anaplastic cells, adenocarcinoma, and squamous cells. The plasma levels of ACTH and cortisol were elevated. Many cells of both the primary and metastatic tumors showed argyrophilia. Almost all the cells of the metastases contained numerous round secretory granules measuring about 117μm in diameter. Small rod‐shaped or larger round secretory granules, measuring 250 and 430 μm respectively, were also found in a few of these cells. The tumors in the right lung, pancreas, and kidney contained high levels of ACTH, β‐MSH, serotonin, histamine, and amylase. This is the first report of ectopic production of these five substances from argyrophil cell caricnoma of the uterine cervix.