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Effect of metastatic cancer on platelet monoamine oxidase activity and serotonin metabolism
Author(s) -
Feldman Jerome M.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197911)44:5<1751::aid-cncr2820440532>3.0.co;2-t
Subject(s) - tryptamine , monoamine oxidase , serotonin , platelet , excretion , tyramine , endocrinology , medicine , monoamine neurotransmitter , 5 hydroxyindoleacetic acid , urinary system , cancer , monoamine oxidase b , pharmacology , chemistry , biochemistry , enzyme , receptor
Platelet monoamine oxidase (MAO) activity and urinary excretion of 5‐hydroxyindoleacetic acid (5‐HIAA), serotonin, tyramine and tryptamine were measured in patients with a variety of metastatic cancers and in healthy control subjects. The patients with cancer had higher platelet MAO activity and lower urinary excretion of 5‐HIAA, serotonin and tyramine than the healthy subjects. The urinary tryptamine excretion was not significantly different in the two groups. At the present time it is unclear if the alterations in platelet MAO activity and monoamine excretion are causally related.