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Clinical toxicologic and pharmacologic studies of gallium nitrate
Author(s) -
Krakoff Irwin H.,
Newman Robert A.,
Goldberg Ronald S.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197911)44:5<1722::aid-cncr2820440528>3.0.co;2-c
Subject(s) - diuresis , medicine , pharmacokinetics , nitrate , gallium , toxicity , pharmacology , renal function , anesthesia , chemistry , organic chemistry
Gallium nitrate, administered intravenously to patients with advanced cancer, produced renal functional abnormalities consistently at a dose of 750 mg/m 2 . The toxicity at that dose could be modified by fluid loading and osmotic diuresis. Pharmacokinetic studies revealed a biphasic half‐life, (T 1/2α = 87 minutes and T 1/2β = 24.5 hours). Osmotic diuresis reduced the urinary concentration of gallium but did not affect serum levels or clearance.